Session 3: Biokémon: Gotta evolve’em all! (Life sicences)

Single-Molecule Study of an RNA Thermosensor

Aurelien Severino, Laura Asensio Puig

Neisseria meningitidis is a human pathogen that has developed subtle mechanisms to evade its host immune system: several genes ensuring its resistance against immune killing are thermoregulated, i.e. increasingly expressed at higher temperature – typically, during host inflammation. The bacterium ability to sense temperature changes is due to special structures occurring in the 5’-UTR region of these genes mRNAs, known …

Nanoparticles for DNA lesions detection

Judit Morlà Folch

The prime objective for every life form is to deliver its genetic material, intact and unchanged, to the next generation. However, during the transference of that material mutations and chemical modifications can occur resulting in variations in the DNA. An inability to respond repairing that DNA damage leads to genetic instability, which in turn may enhance the rate of suffering …

Cultured Neuronal Networks

Estefania Estevez Priego, Lluís Hernández Navarro

Uncovering the relationship between neuronal activity (electric signal transmission) and structural connectivity (physical connection between neurons) is one of the major challenges in neuroscience. In this direction, we study activity changes caused by external perturbations in a network of living neurons. Our experimental set up is based on in vitro neuronal cultures, together with fluorescence imaging to monitor activity at …

Epigenetic therapies: new strategies for the treatment of neuroblastoma

Carlos Jiménez Jiménez, Luz Jubierre Zapater

Pediatric cancer is the main cause of death by disease in children in developed countries. Although advances in therapy have increased the survival of affected children during the last decades, there is still a group of patients unable to respond to therapy and overcome the disease. This is the reason why research on new therapeutic approaches is a must. In …

Brain tumors and environmental risk factors in young people- A literature review

Angela Zumel Marne

Background: Little is known about the brain tumors (BT) etiology apart from genetic factors and ionizing radiation exposure. The main objective was to review the scientific literature on the association of environmental factors exposures. Methods: PUBMED, Embase, Cochrane Library, Scopus, Web of science, IME databases were searched to identify the publications. Results: Sixty-five publications were identified on environmental exposures. The …

Boiling the frog: thermal adaptation in mountain tropical frogs

Pol Pintanel Costa

Global warming is seriously threatening amphibians. One of the main causes is the direct effect of the increase in average and extreme  temperatures, in addition to the indirect consequences that entail the  destruction and fragmentation of their terrestrial and aquatic  habitats. On the other hand, we have very little information of the  traits associated with thermal physiology, especially in tropical  …

IS IT SAFE TO DRINK OUR WATER?

Juan Francisco Ayala Cabrera, Clara Pérez Ràfols, Alejandro Fernández Pumarega

Water plays a crucial role in the environment, being essential for life development and one of the most valuable resources for humanity. In fact, it is recommended to drink 1.5-2 litters of water daily and, for instance, we use it to cook most of our food. Moreover, the water quality does not only affect human life but also other living …

Effect of body weight and composition on lung function development in adolescents and decline in adults

Gabriela Prado Peralta

The burden of overweight and obesity has reached epidemic levels globally. According to the World Health Organization in 2014, more than 1.9 billion adults and 41 million children under the age of 5 years were overweight. Overweight and obesity are major risk factors for non-communicable diseases such as cardiovascular diseases or diabetes. More recently, overweight and obesity have been longitudinally …